Biological indicators of chemoresistance: an ex vivo analysis of γH2AX and p53 expression in feline injection-site sarcomas
Abstract Journal Background The response of soft tissue sarcomas to cytotoxic chemotherapy is inconsistent.Biomarkers of chemoresistance or chemosensitivity are needed in order to identify appropriate patients for treatment.Given that many chemotherapeutics kill cells through direct DNA interactions, we hypothesized that upregulation of DNA damage